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Non-Target Screening

We offer non-target screening of all organic trace substances detectable by HPLC-HRMS in aqueous samples as part of our environmental analyses:

  • Detection of all detectable substances (known and unknown) with high mass accuracy and resolution
  • Storage and creation of a substance database for each sample, enabling future retrospective searches or analyses
  • Sum formula suggestions, information on structure, and possible identification of unknown substances
  • Local tracking and temporal trend analyses of detectable substances

This means that both known and unknown substances are monitored without prior knowledge of the composition of the sample.

For you, this means: creating a more comprehensive picture of your samples and monitoring them using HPLC-HRMS.

How can we support you?

Our engagement options offer you maximum flexibility to fulfil your specific analysis needs. Regardless of the option you choose, our experienced team of experts is ready to guide you through the process.

Contact us to discuss the right option for your requirements and take your analyses to the next level.

Commissioning options

1) Measurement: Non-target screening with data backup under research conditions

  • Includes comprehensive non-target screening of organic micropollutants using HPLC-HRMS.
  • Detection of all detectable substances in your samples, known or unknown.
  • Data backup for a period of 3 years to enable retrospective analyses.
  • This service does not include report generation/analysis and is ideal for later research purposes.

2a) Evaluation: Comparative analysis with comprehensive information

  • Supplement to the measurement: Non-target screening
  • Each sample is analysed in comparison with up to five reference samples
  • Delivery of possible sum formula suggestions and structural information.
  • This evaluation enables you to recognise correlations between samples and to go deeper into the analysis.

2b) Trend analysis and tracking of known and unknown substances

  • Supplement to measurement: non-target screening
  • Analysis of at least 10 samples for trend analysis and local tracking.
  • Creation of a “feature” database for a comprehensive overview.
  • Sum formula suggestions and structural information are provided.
  • This analysis provides deep insights into the temporal development and spatial distribution of the substances.

2c) Customised analysis for specific projects as agreed with the customer

  • The prerequisite is the commissioning of position 1.
  • This option is ideal for customised research projects.
  • Individual analyses are carried out according to customer requirements, e.g. for the structural elucidation of unknown substances or contamination tracing.

More details

Non-target screening with HPLC-HRMS: Comprehensive analysis of organic trace substances in aqueous samples

In today’s world, where environmental inputs are becoming increasingly complex, it is crucial to have powerful analytical techniques to capture the diversity of substances present in samples. This is where non-target screening using high-performance liquid chromatography coupled with high-resolution mass spectrometry (HPLC-HRMS) can make a significant contribution. This technique enables the comprehensive detection of organic trace substances in aqueous samples, regardless of whether these substances are already known or not.

Comprehensive detection with high mass accuracy and resolution

Our non-target screening approach is based on the use of HPLC-HRMS, a technique that enables the detection of a wide range of compounds with high mass accuracy and excellent resolution. All detectable substances are captured, whether they are already known in databases or completely unknown.

Substance database and retrograde analyses

A key advantage of non-target screening is the storage and creation of a comprehensive substance database for each sample. This enables future retrospective searches and analyses to monitor changes in the sample content over time or to identify specific substances in a targeted manner.

Identification of unknowns

Our experts can not only identify known compounds, but also analyse unknown substances in detail. By providing suggested molecular formulae, structural information and possible identification of unknown substances, we help you to gain a better understanding of the composition of your samples. In combination with other techniques such as HPLC or NMR.

Local tracking and temporal trend analyses

With the non-target screening approach, we also offer the possibility of localised tracking of detectable substances and the performance of temporal trend analyses. This enables a comprehensive assessment of environmental changes, sample sources and potential hazards.

Advantages for you

The benefits of non-target screening are clear: you get a more comprehensive picture of your samples and can closely monitor their contents thanks to HPLC-HRMS technology. This approach is particularly valuable as it allows you to detect both known and unknown substances that may be present in your samples.

Our support

Our team of experienced analysts and scientists is available to support you in performing non-target screening for your samples. We offer you not only state-of-the-art analytical technology, but also comprehensive expertise in the interpretation of the data obtained. Contact us to find out more about how we can help you gain a deeper understanding of the composition of your samples and identify potential risks

Contact

Dr. Marcel Klees
Dr. Marcel Klees

C601

C601

D-41538 Dormagen

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